Biodegradable Microcapsular Drug Delivery Systems: Manufacturing Methodology, Release Control and Targeting Prospects

An overview of the subject of biodegradable microcapsular drug delivery systems is presented from a polymer chemist's viewpoint. Various polymerization and microencapsulation techniques (including emulsion polymerization, interfacial polycondensation, suspension crosslinking, coacervation/phase separation and solvent evaporation/extraction) suitable for the preparation of biodegradable microcapsules based on proteins, polysaccharides, polyesters, polyamides, or cyanoacrylates are described. Drug release from biodegradable microcapsules is discussed, and examples are presented to illustrate how the rate of drug release can be controlled by adjusting parameters such as microcapsule size, porosity, and crosslinking. Prospects of site-specific chemotherapy by means of passive and active targeting of microcapsular drug carriers are also analyzed.