DNA CONTENT AND THE PROLIFERATION MARKER KI-67 AS PROGNOSTIC INDICATORS IN RENAL-CELL CARCINOMA

被引：14
作者：
PAPADOPOULOS, I
WEICHERTJACOBSEN, K
SPRENGER, E
WACKER, HH
机构：
[1] Department of Urology, University of Kiel
[2] Institute of Cytopathology, University of Kiel
[3] Institute of Pathology, University of Kiel
来源：
UROLOGIA INTERNATIONALIS | 1994年 / 53卷 / 04期
关键词：
RENAL CELL CARCINOMA; DNA CONTENT; PROLIFERATION RATE (KI-67);
D O I：
10.1159/000282669
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Patients suffering from renal cell carcinoma have a generally poor prognosis. Even cases that are clinically in comparable stages can, however, take quite different courses. The basic prognostic factors, histological grade and TNM stage do not do justice to the heterogeneous biological behavior of this tumor entity. In this study, the possible prognostic indicators, DNA content and proliferation rate, assessed with Ki-67, were compared with the histological grade and the TNM stage. Though there was no correlation between the proliferation rate (Ki-67) and the two, there was a significant correlation between DNA content and both histological grade and TNM stage.
引用
收藏
页码：181 / 185
页数：5
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