DNA CONTENT AND THE PROLIFERATION MARKER KI-67 AS PROGNOSTIC INDICATORS IN RENAL-CELL CARCINOMA

被引：14
作者：
PAPADOPOULOS, I
WEICHERTJACOBSEN, K
SPRENGER, E
WACKER, HH
机构：
[1] Department of Urology, University of Kiel
[2] Institute of Cytopathology, University of Kiel
[3] Institute of Pathology, University of Kiel
来源：
UROLOGIA INTERNATIONALIS | 1994年 / 53卷 / 04期
关键词：
RENAL CELL CARCINOMA; DNA CONTENT; PROLIFERATION RATE (KI-67);
D O I：
10.1159/000282669
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Patients suffering from renal cell carcinoma have a generally poor prognosis. Even cases that are clinically in comparable stages can, however, take quite different courses. The basic prognostic factors, histological grade and TNM stage do not do justice to the heterogeneous biological behavior of this tumor entity. In this study, the possible prognostic indicators, DNA content and proliferation rate, assessed with Ki-67, were compared with the histological grade and the TNM stage. Though there was no correlation between the proliferation rate (Ki-67) and the two, there was a significant correlation between DNA content and both histological grade and TNM stage.
引用
收藏
页码：181 / 185
页数：5
相关论文
共 50 条
  • [21] Knockdown of Ki-67 by small interfering RNA leads to inhibition of proliferation and induction of apoptosis in human renal carcinoma cells
    Zheng, JN
    Ma, TX
    Cao, JY
    Sun, XQ
    Chen, JC
    Li, W
    Wen, RM
    Sun, YF
    Pei, DS
    LIFE SCIENCES, 2006, 78 (07) : 724 - 729
  • [22] Prognostic and clinicopathological value of Ki-67/MIB-1 expression in renal cell carcinoma: a meta-analysis based on 4579 individuals
    Wang, Zhun
    Xie, Hui
    Guo, Linpei
    Cai, Qiliang
    Shang, Zhiqun
    Jiang, Ning
    Niu, Yuanjie
    CANCER MANAGEMENT AND RESEARCH, 2017, 9 : 679 - 689
  • [23] CYTOGENETIC AND FLOW CYTOMETRIC DNA ANALYSIS IN RENAL-CELL CARCINOMA
    LJUNGBERG, B
    NORDENSON, I
    ROOS, G
    EUROPEAN UROLOGY, 1991, 19 (01) : 59 - 64
  • [24] MULTIVARIATE EVALUATION OF PROGNOSTIC DETERMINANTS FOR RENAL-CELL CARCINOMA
    TAKASHI, M
    NAKANO, Y
    SAKATA, T
    MIYAKE, K
    HAMAJIMA, N
    UROLOGIA INTERNATIONALIS, 1993, 50 (01) : 6 - 12
  • [25] p53 immunoreactivity correlates with Ki-67 and bcl-2 expression in renal cell carcinoma
    Olumi, AF
    Weidner, N
    Presti, JC
    UROLOGIC ONCOLOGY, 2001, 6 (02): : 63 - 67
  • [26] PROGNOSTIC VALUE OF NUCLEAR GRADE OF RENAL-CELL CARCINOMA
    BRETHEAU, D
    LECHEVALLIER, E
    DEFROMONT, M
    SAULT, MC
    RAMPAL, M
    COULANGE, C
    CANCER, 1995, 76 (12) : 2543 - 2549
  • [27] PROGNOSTIC-SIGNIFICANCE OF INCIDENTAL RENAL-CELL CARCINOMA
    BRETHEAU, D
    LECHEVALLIER, E
    EGHAZARIAN, C
    GRISONI, V
    COULANGE, C
    EUROPEAN UROLOGY, 1995, 27 (04) : 319 - 323
  • [28] Analysis of immunhistochemical expression of PCNA (proliferating cellular nuclear antigen) and MIB-1 (Ki-67 antigen) as a prognostic indicator for renal cell carcinoma
    Onda, H
    Yasuda, M
    Serizawa, A
    Osamura, RY
    Kawamura, N
    AKTUELLE UROLOGIE, 2000, 31 : 64 - 67
  • [29] Histopathologic prognostic indicators for renal cell carcinoma
    Delahunt, B
    SEMINARS IN DIAGNOSTIC PATHOLOGY, 1998, 15 (01) : 68 - 76
  • [30] PROLIFERATING CELL NUCLEAR ANTIGEN AND KI-67 IN LUNG-CARCINOMA - CORRELATION WITH DNA FLOW CYTOMETRIC ANALYSIS
    KAWAI, T
    SUZUKI, M
    KONO, S
    SHINOMIYA, N
    ROKUTANDA, M
    TAKAGI, K
    OGATA, T
    TAMAI, S
    CANCER, 1994, 74 (09) : 2468 - 2475
12345