ISLET-CELL ANTIBODIES AND BETA-CELL FUNCTION IN GESTATIONAL DIABETIC WOMEN - COMPARISON TO FIRST-DEGREE RELATIVES OF TYPE-1 (INSULIN-DEPENDENT) DIABETIC SUBJECTS

被引：21

作者：

MAURICIO, D ^{[1
]}

CORCOY, R ^{[1
]}

CODINA, M ^{[1
]}

MORALES, J ^{[1
]}

BALSELLS, M ^{[1
]}

DELEIVA, A ^{[1
]}

机构：

[1] UNIV AUTONOMA BARCELONA,HOSP SANTA CREU & SANT PAU,SERV ENDOCRINOL & NUTR,E-08025 BARCELONA,SPAIN

来源：

DIABETIC MEDICINE | 1995年 / 12卷 / 11期

关键词：

ISLET CELL ANTIBODIES; GESTATIONAL DIABETES MELLITUS; PREGNANCY; INTRAVENOUS GLUCOSE TOLERANCE TEST; AUTOIMMUNITY;

D O I：

10.1111/j.1464-5491.1995.tb00414.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In order to further characterize women with islet cell antibodies (ICA) at the diagnosis of gestational diabetes (GDM), we aimed to compare titres and persistence as well as B-cell function with those of ICA+ first-degree relatives of Type 1 (insulin-dependent) diabetic subjects. Titres at detection of ICA were compared between 69 women with GDM and 53 relatives. Persistence of ICA positivity was investigated in 33 ICA+ gestational diabetic women and 39 relatives (mean follow-up: 13 months). Assessment of the acute insulin response, through an intravenous glucose tolerance test (IVGTT), was carried out in 9 ICA+ women with previous GDM and normal oral glucose tolerance, and their results were compared to those of a control group (9 women) and a group of 12 adult ICA+ relatives. In comparison with first-degree relatives, women with GDM had a higher ICA prevalence, especially with titres of <20 JDF, and a similar persistence at follow-up. Women with ICA at diagnosis of GDM and normal oral glucose tolerance after pregnancy showed a decreased insulin response to glucose as compared to the control group. Results of the IVGTT closely paralleled those from adult ICA+ relatives. It is concluded that ICA+ gestational diabetic women share with ICA+ first-degree relatives of Type 1 diabetic subjects metabolic and immunologic disturbances.

引用

页码：1009 / 1014

页数：6

共 24 条

[1]

Freinkel N., Metzger BE, Phelps RL, Dooley SL, Ogata ES, Radvany RM, Et al., Gestational diabetes mellitus: heterogeneity of maternal age, weight, insulin secretion, HLA antigens, and islet cell antibodies and the impact of maternal metabolism on pancreatic B‐cell and somatic development in the offspring, Diabetes, 34, pp. 1-7, (1985)

[2]

O'Sullivan JB, Diabetes mellitus after GDM, Diabetes, 29, pp. 131-135, (1991)

[3]

Steel JM, Irvine WJ, Clarke BF, The significance of pancreatic islet cell antibody and abnormal glucose tolerance during pregnancy, J Clin Lab Immunol, 4, pp. 83-85, (1980)

[4]

Rubinstein P., Walker M., Krassner J., Carrier C., Carpenter C., Dobersen MJ, Et al., HLA antigens and islet cell antibodies in gestational diabetes, Hum Immunol, 3, pp. 271-275, (1981)

[5]

Fallucca F., Di Mario U., Gargiulo P., Iavicoli M., Galfo C., Contreas G., Et al., Humoral immunity in diabetic pregnancy: interrelationships with maternal/neonatal complications and maternal metabolic control, Diabete Metab, 11, pp. 387-395, (1985)

[6]

Catalano PM, Tyzbir ED, Sims EAH, Incidence and significance of islet cell antibodies in women with previous gestational diabetes, Diabetes Care, 13, pp. 478-482, (1990)

[7]

Bell DSH, Barger BO, Go RCP, Goldenberg RL, Perkins LL, Vanichanan CJ, Et al., Risk factors for gestational diabetes in black population, Diabetes Care, 13, pp. 1196-1201, (1990)

[8]

Mauricio D., Corcoy R., Codina M., Balsells M., Puig-Domingo M., Pou JM, Et al., Islet cell antibodies identify a subset of gestational diabetic women with higher risk of developing diabetes mellitus shortly after pregnancy, Diab Nutr Metab, 5, pp. 237-241, (1992)

[9]

Ziegler AG, Hillebrand B., Rabl W., Mayrhofer M., Hummel M., Mollenhauer U., Et al., On the appearance of islet associated autoimmunity in offspring of diabetic mothers: a prospective study from birth, Diabetologia, 36, pp. 402-408, (1993)

[10]

Damm P., Kuhl C., Buschard K., Jakobsen BK, Svejgaard A., Sodoyez-Goffaux F., Et al., Prevalence and predictive value of islet cell antibodies and insulin antibodies in women with gestational diabetes, Diabetic Med, 11, pp. 558-563, (1994)

← 1 2 3 →