Treatment of Aggressive Prolactin-Secreting Pituitary Adenomas with Adjuvant Temozolomide Chemotherapy: A Review

被引：9

作者：

Moisi, Marc ^{[1
,2
]}

Cruz, Aurora S. ^{[3
,4
,5
]}

Benkers, Tara ^{[6
]}

Rostad, Steven ^{[7
]}

Broyles, Frances Broyles ^{[8
]}

Yuen, Kevin ^{[9
]}

Mayberg, Marc ^{[10
]}

机构：

[1] Wayne State Univ, Seattle Sci Fdn, Detroit, MI 48202 USA

[2] Wayne State Univ, Neurol Surg, Detroit, MI 48202 USA

[3] Univ Louisville, Neurol Surg, Louisville, KY 40292 USA

[4] Univ Calif Irvine, Neurol Surg, Irvine, CA USA

[5] Swedish Neurosci Inst, Neurol Surg, Seattle, WA USA

[6] Swedish Neurosci Inst, Neurooncol, Seattle, WA USA

[7] CellNetix, Pathol, Seattle, WA USA

[8] Swedish Neurosci Inst, Endocrinol, Seattle, WA USA

[9] Swedish Neurosci Inst, Swedish Pituitary Ctr, Seattle, WA USA

[10] Swedish Neurosci Inst, Seattle, WA USA

来源：

CUREUS | 2016年 / 8卷 / 06期

关键词：

aggressive pituitary tumor; prolactinoma; radiosurgery; temozolomide;

D O I：

10.7759/cureus.658

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Most prolactin-secreting pituitary adenomas demonstrate slow growth and are effectively managed with medical/surgical therapy. Rarely, these tumors can behave aggressively with rapid growth and invasion of local tissues, and are refractory to medical, surgical, or radio-surgical therapies. We report a case of a prolactin-secreting adenoma in a young woman, which became progressively aggressive and refractory to usual treatment modalities, but responded to treatment with the chemotherapeutic agent temozolomide. In addition, we review the literature for treatment of refractory adenomas with temozolomide. The clinical and pathologic characteristics of aggressive prolactin-secreting adenomas are reviewed, as well as their response to dopamine agonists, surgery, radiotherapy, and chemotherapy.

引用

页数：17

共 26 条

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