ACUTE LYMPHOBLASTIC-LEUKEMIA (ALL) - DETECTION OF MINIMAL RESIDUAL DISEASE (MRD) AT FLOW-CYTOMETRY

被引：52

作者：

ORFAO, A

CIUDAD, J

LOPEZBERGES, MC

LOPEZ, A

VIDRIALES, B

CABALLERO, MD

VALVERDE, B

GONZALEZ, M

SANMIGUEL, JF

机构：

[1] Servicio General de Citometria y Servicio de Hematologia, Universidad de Salamanca

来源：

LEUKEMIA & LYMPHOMA | 1994年 / 13卷

关键词：

D O I：

10.3109/10428199409052682

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the present study the usefulness of a method combining multiple staining direct immunofluorescence technique together with flow cytometry in order to predict relapse in ALL is analyzed in a group of 47 patients (11 T-ALL and 36 B-ALL). Results show that this method can be applied to at least two-thirds of all ALL patients being specially useful for the T-ALL cases (100% vs 56%) as this corresponding to the incidence of ''aberrant'' phenotypes. The detection of an increase in the percentage of bone marrow cells displaying ''aberrant'' phenotypes in two consecutive samples from the same patient is of great help on predicting relapse (sensitivity of 92% and specificity of 75%).

引用

页码：87 / 90

页数：4

共 30 条

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