THE ROLE OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE WITH A HIGH-AFFINITY FOR BENZYLAMINE (BZ SSAO) IN THE CATABOLISM OF HISTAMINE IN THE MESENTERIC ARTERIAL BED OF THE RAT

被引：9

作者：

BUFFONI, F

BANCHELLI, G

IGNESTI, G

PIRISINO, R

RAIMONDI, L

机构：

[1] Department of Pharmacology, University of Florence, Florence, 1-50134, viale G. B. Morgagni

来源：

AGENTS AND ACTIONS | 1994年 / 42卷 / 1-2期

关键词：

HISTAMINE; SEMICARBAZIDE; SENSITIVE AMINE; OXIDASES; RAT MESENTERIC ARTERIAL BED;

D O I：

10.1007/BF02014291

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the mesenteric arterial bed of the rat the semicarbazide-sensitive amine oxidase with a high affinity for benzylamine (Bz. SSAO) (E.C. 1.4.3.6) is also able to oxidize histamine. In the perfused mesenteric arterial bed of the rat the complete inhibition of the Bz. SSAO obtained with a specific inhibitor, B24, almost completely reduces the efflux of imidazole acetic acid and increases the relaxing effect of histamine. Bz. SSAO appears to be the only enzyme present in these blood vessels able to catabolize histamine.

引用

页码：1 / 6

页数：6

共 27 条

[1] A STUDY OF THE BIOCHEMICAL PHARMACOLOGY OF 3,5-ETHOXY-4-AMINOMETHYLPYRIDINE (B24), A NOVEL AMINE OXIDASE INHIBITOR WITH SELECTIVITY FOR TISSUE BOUND SEMICARBAZIDE-SENSITIVE AMINE OXIDASE ENZYMES [J].