THE MITOCHONDRIAL ALDEHYDE DEHYDROGENASE GENE RESIDES IN AN HTF ISLAND BUT IS EXPRESSED IN A TISSUE-SPECIFIC MANNER

被引：18
|
作者：
DIPPLE, KM
CRABB, DW
机构：
[1] INDIANA UNIV, SCH MED, DEPT MED, 975 W WALNUT ST, IB 424, INDIANAPOLIS, IN 46202 USA
[2] INDIANA UNIV, SCH MED, DEPT BIOCHEM & MOLEC BIOL, INDIANAPOLIS, IN 46202 USA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 193卷 / 01期
关键词：
D O I：
10.1006/bbrc.1993.1640
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The tissue distribution of mitochondrial aldehyde dehydrogenase (ALDH2) in rats was analyzed by activity assays, and by Western and Northern blotting. ALDH2 was expressed at highest levels in liver. The mRNA levels were intermediate in the kidney and lung, while lower levels were found in spleen and heart. The transcript was undetectable in other tissues tested. The human ALDH2 5’ flanking region (-200 to +60) contains similar numbers of CpG and GpC dinucleotides and the rat ALDH2 gene was undermethylated in liver, kidney, and spleen. This suggests that the ALDH2 promoter resides in a Hpa II tiny fragment (HTF) island, unlike most genes expressed in a tissue-specific manner. © 1993 Academic Press, Inc.
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页码：420 / 427
页数：8
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