ANTITHROMBIN-III - STRUCTURAL AND FUNCTIONAL-ASPECTS

被引：61

作者：

MOUREY, L

SAMAMA, JP

DELARUE, M

CHOAY, J

LORMEAU, JC

PETITOU, M

MORAS, D

机构：

[1] INST BIOL MOLEC & CELLULAIRE, CRISTALLOG BIOL LAB, CNRS, 15 RUE RENE DESCARTES, F-67084 STRASBOURG, FRANCE

[2] SANOFI RECH, F-94256 GENTILLY, FRANCE

来源：

BIOCHIMIE | 1990年 / 72卷 / 08期

关键词：

antithrombin III; heparin; serpin superfamily; X-ray structure;

D O I：

10.1016/0300-9084(90)90123-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antithrombin III is a plasma gylcoprotein responsible for thrombin inhibition in the blood coagulation cascade. The X-ray structure of its cleaved form has been determined and refined to 3.2 Å resolution. The overall topology is similar to that of ω1-antitrypsin, another member of the serpin (serine protease inhibitor) superfamily. The biological activity of antithrombin III is mediated by a polysaccharide, heparin. The binding site of this effector is described. A possible structural transition from the native to the cleaved structure is discussed. © 1990.

引用

页码：599 / 608

页数：10

共 64 条

[1] OMITMAP - AN ELECTRON-DENSITY MAP SUITABLE FOR THE EXAMINATION OF ERRORS IN A MACROMOLECULAR MODEL [J].