TELOMERES AND TELOMERASE IN AGING AND CANCER

被引：301
作者：
HARLEY, CB
VILLEPONTEAU, B
机构：
[1] Geron Corporation, Menlo Park, CA 94025
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 02期
关键词：
D O I：
10.1016/0959-437X(95)80016-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Telomeres are maintained by the novel ribonucleoprotein enzyme telomerase. Telomerase activity is repressed in most somatic human cells, leading to telomere loss during replicative aging in-vivo and in vitro. However, telomerase appears to be reactivated in essentially all human cancers. With the recent cloning of the RNA component of telomerase from several species, the stage is now set for critical tests of the role of telomeres and telomerase in aging and cancer.
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页码：249 / 255
页数：7
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