MECHANISMS OF DISEASE - HYPOXIA OF THE RENAL MEDULLA - ITS IMPLICATIONS FOR DISEASE

被引:900
作者
BREZIS, M
ROSEN, S
机构
[1] BETH ISRAEL HOSP,DEPT PATHOL,BOSTON,MA 02215
[2] HARVARD UNIV,SCH MED,BOSTON,MA
关键词
D O I
10.1056/NEJM199503093321006
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In land mammals, a major task of the kidney is to reabsorb water to allow survival in a dry environment. Water conservation is enhanced by the renal medulla, which concentrates the urine to a level up to four times the osmolality of plasma. To produce this unique gradient of osmolality, the medulla has a countercurrent system of vessels and tubules that dictates active reabsorption of sodium in a milieu poor in oxygen (Figure 1).1 In this review, we describe how hypoxia of the medulla may relate to susceptibility to acute and chronic renal injury. The Renal Medullary Concentrating Mechanism as. © 1995, Massachusetts Medical Society. All rights reserved.
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收藏
页码:647 / 655
页数:9
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