PERIPHERAL MICROCHIMERISM IN LONG-TERM CADAVERIC-KIDNEY ALLOGRAFT RECIPIENTS

被引：113

作者：

SUBERBIELLE, C

CAILLATZUCMAN, S

LEGENDRE, C

BODEMER, C

NOEL, LH

KREIS, H

BACH, JF

机构：

[1] HOP NECKER ENFANTS MALAD,INSERM,U25,F-75015 PARIS,FRANCE

[2] HOP NECKER ENFANTS MALAD,SERV TRANSPLANTAT RENALE,PARIS,FRANCE

[3] HOP NECKER ENFANTS MALAD,SERV DERMATOL,F-75730 PARIS,FRANCE

来源：

LANCET | 1994年 / 343卷 / 8911期

关键词：

D O I：

10.1016/S0140-6736(94)92583-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Microchimerism after allogeneic organ transplantation may be a mechanism for induction of donor-specific graft acceptance. However, the frequency of chimerism and its relevance in long-term tolerance are uncertain. We studied 15 long-surviving (more than 20 years) cadaveric-kidney transplant recipients for the systemic presence of donor alleles with allele-specific genomic amplification of DRB1 and H-Y loci. Microchimerism was observed in 1 case in peripheral blood and in 4 cases in shin. Chimerism and number of HLA alleles shared by donor and recipient were not correlated. This low frequency of microchimerism in long-term kidney allograft recipients raises doubts about a major participation of chimerism in donor-specific tolerance.

引用

收藏

页码：1468 / 1469

页数：2

相关论文

共 10 条

[1] DONOR-DERIVED LONG-TERM MULTILINEAGE HEMATOPOIESIS IN A LIVER-TRANSPLANT RECIPIENT [J].

COLLINS, RH ;

ANASTASI, J ;

TERSTAPPEN, LWMM ;

NIKAEIN, A ;

FENG, JJ ;

FAY, JW ;

KLINTMALM, G ;

STONE, MJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1993, 328 (11) :762-765

[2] CYTOKINES AND PERIPHERAL TOLERANCE TO ALLOANTIGEN [J].

DALLMAN, MJ ;

WOOD, KJ ;

HAMANO, K ;

BUSHELL, AR ;

MORRIS, PJ ;

WOOD, MJA ;

CHARLTON, HM .

IMMUNOLOGICAL REVIEWS, 1993, 133 :5-18

[3] PCR DETECTION OF DISTAL YP-SEQUENCES IN AN XX TRUE HERMAPHRODITE [J].

NAKAGOME, Y ;

SEKI, S ;

FUKUTANI, K ;

NAGAFUCHI, S ;

NAKAHORI, Y ;

TAMURA, T .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1991, 41 (01) :112-114

[4] HLA-DR TYPING BY PCR AMPLIFICATION WITH SEQUENCE-SPECIFIC PRIMERS (PCR-SSP) IN 2 HOURS - AN ALTERNATIVE TO SEROLOGICAL DR TYPING IN CLINICAL-PRACTICE INCLUDING DONOR-RECIPIENT MATCHING IN CADAVERIC TRANSPLANTATION [J].

OLERUP, O ;

ZETTERQUIST, H .

TISSUE ANTIGENS, 1992, 39 (05) :225-235

[5] INDUCTION OF DONOR-SPECIFIC UNRESPONSIVENESS BY INTRATHYMIC ISLET TRANSPLANTATION [J].

POSSELT, AM ;

BARKER, CF ;

TOMASZEWSKI, JE ;

MARKMANN, JF ;

CHOTI, MA ;

NAJI, A .

SCIENCE, 1990, 249 (4974) :1293-1295

[6] MIXED CHIMERISM AND PERMANENT SPECIFIC TRANSPLANTATION TOLERANCE INDUCED BY A NONLETHAL PREPARATIVE REGIMEN [J].

SHARABI, Y ;

SACHS, DH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (02) :493-502

[7] CHIMERISM AFTER LIVER-TRANSPLANTATION FOR TYPE-IV GLYCOGEN-STORAGE-DISEASE AND TYPE-1 GAUCHERS-DISEASE [J].

STARZL, TE ;

DEMETRIS, AJ ;

TRUCCO, M ;

RICORDI, C ;

ILDSTAD, S ;

TERASAKI, PI ;

MURASE, N ;

KENDALL, RS ;

KOCOVA, M ;

RUDERT, WA ;

ZEEVI, A ;

VANTHIEL, D .

NEW ENGLAND JOURNAL OF MEDICINE, 1993, 328 (11) :745-749

[8] CHIMERISM AND DONOR-SPECIFIC NONREACTIVITY 27 TO 29 YEARS AFTER KIDNEY ALLOTRANSPLANTATION [J].

STARZL, TE ;

DEMETRIS, AJ ;

TRUCCO, M ;

ZEEVI, A ;

RAMOS, H ;

TERASAKI, P ;

RUDERT, WA ;

KOCOVA, M ;

RICORDI, C ;

ILDSTAD, S ;

MURASE, N .

TRANSPLANTATION, 1993, 55 (06) :1272-1277

[9] SYSTEMIC CHIMERISM IN HUMAN FEMALE RECIPIENTS OF MALE LIVERS [J].

STARZL, TE ;

DEMETRIS, AJ ;

TRUCCO, M ;

RAMOS, H ;

ZEEVI, A ;

RUDERT, WA ;

KOCOVA, M ;

RICORDI, C ;

ILDSTAD, S ;

MURASE, N .

LANCET, 1992, 340 (8824) :876-877

[10] SELECTION OF UNRELATED DONORS FOR BONE-MARROW TRANSPLANTATION IS IMPROVED BY HLA CLASS-II GENOTYPING WITH OLIGONUCLEOTIDE HYBRIDIZATION [J].

TIERCY, JM ;

MOREL, C ;

FREIDEL, AC ;

ZWAHLEN, F ;

GEBUHRER, L ;

BETUEL, H ;

JEANNET, M ;

MACH, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (16) :7121-7125