CLINICAL-EVALUATION OF THE ANTIBODY AGAINST CORE PROTEIN OF HEPATITIS-C VIRUS

被引：2

作者：

OHKOSHI, S

WATANABE, M

KUWANA, K

TAWARAYA, H

KAMIMURA, T

ASAKURA, H

机构：

[1] Third Department of Internal Medicine, School of Medicine, Niigata University, Niigata, 951

来源：

GASTROENTEROLOGIA JAPONICA | 1993年 / 28卷

关键词：

D O I：

10.1007/BF02989212

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The authors measured antibody against the core protein of hepatitis C virus (HCV) in patients with acute or chronic hepatitis and healthy blood donors, and compared the results with the one obtained from anti-C100-3 assay. To characterize this antibody (anti-core), we also examined the patients with past posttransfusional acute non-A, non-B hepatitis and investigated how frequently viraemia of HCV persisted after the acute phase of hepatitis detecting HCV RNA by polymerase chain reaction. Anti-core was detected in 109/128 (85.2%) of patients with chronic hepatitis and the detection rate of anti-C100-3 was 95/128 (74.2%), respectively. Twenty seven of 33 (82%) patients with past postransfusional acute hepatitis were still positive for anti-core concomitant with the presence of anti-C100-3, having accompanied the presence of HCV RNA in 24/33 (73%). Eight of 2,020 (0.4%) healthy blood donors who were negative for anti-C100-3 were anti-core-positive, and all 5 patients transfused with this anti-core positive blood suffered from posttransfusion hepatitis C. Thus, anti-core antibody was closely associated with the presence of HCV RNA and considered to be a reliable marker of the virus replication. © 1993 The Japanese Society of Gastroenterology.

引用

页码：80 / 83

页数：4

共 13 条

[1]

Choo Q-L, Kuo G., Weiner A.J., Et al., Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome, Science, 244, pp. 359-362, (1989)

[2]

Kuo G., Choo Q-L, Alter A.J., Et al., An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepetitis, Science, 244, pp. 362-364, (1989)

[3]

Miyamura T., Saito I., Katayama T., Et al., Detection of antibody against antigen expressed by molecularly cloned hepatitis C virus cDNA: Application to diagnosis and blood screening for posttransfusion hepatitis, Proc Natl Acad Sci USA, 87, pp. 983-987, (1990)

[4]

Weiner A.J., Kuo G., Bradly D.W., Et al., Detection of hepatitis C viral sequence in non-A, non-B hepatitis, Lancet, 335, pp. 1-3, (1990)

[5]

Ohkoshi S., Kato N., Kinoshita T., Et al., Detection of hepatitis C virus RNA in sera and liver tissues of non-A, non-B hepatitis patients using the polymerase chain reaction, Jpn J Cancer Res, 81, pp. 862-865, (1990)

[6]

Chiba J., Ohba Y., Matsuura Y., Et al., Serodiagnosis of hepatitis C virus (HCV) infection with an HCV core proten molecularly expressed by a recombinant baculovirus, Proc Natl Acad Sci USA, 88, pp. 4641-4645, (1991)

[7]

Muraiso K., Hijikata M., Ohkoshi S., Et al., A structural protein of hepatitis C virus expressed in E. coli facilitates accurate detection of hepatitis C virus, Biochem Biophys Res Commun, 172, pp. 511-516, (1990)

[8]

Muraiso K., Hijikata M., Kato N., Et al., Detection of hepatitis C infection by enzyme-linked immunosorbent assay system using core protein expressed in Esherichia coli, Jpn J Cancer Res, 82, pp. 879-882, (1991)

[9]

Garson J.A., Tedder R.S., Briggs M., Et al., Detection of hepatitis C viral sequences in blood donations by “nested” polymerase chain reaction and prediction of infectivity, Lancet, 335, pp. 1419-1422, (1990)

[10]

Kato N., Hijikata M., Ootsuyama Y., Et al., Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis, Proc Natl Acad Sci USA, 87, pp. 9524-9528, (1990)

← 1 2 →