Management of Recurrent Pregnancy Loss

被引:0
|
作者
Kwak, In Pyung [1 ]
机构
[1] Pochon CHA Univ Coll Med, CHA Gen Hosp, Dept Obstet & Gynecol, Seoul, South Korea
来源
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION | 2006年 / 49卷 / 04期
关键词
Recurrent pregnancy loss; Spontaneous abortion; Miscarriage; Fetal death;
D O I
10.5124/jkma.2006.49.4.369
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Recurrent pregnancy loss (RPL) is defined as three or more consecutive spontaneous abortions. It affects about 1% of couples attempting pregnancy. Most of these pregnancy losses are unrecognized. Among the pregnancies that are clinically recognized, loss occurs in 15% before 20 weeks of gestation. Only about 50% of women with RPL have an identifiable etiology. Genetic abnormalities are responsible for RPL in 2 similar to 4% of these couples, most with balanced translocation. Luteal phase defect might be present in 25 similar to 30% of women with RPL; however, progesterone supplementation for miscarriage prevention has not been adequately studied. Uterine abnormalities might also result in RPL. Inherited thrombophilias appear to be associated with fetal death, and antenatal thromboprophylaxis might be beneficial for some women with an inherited thrombophilia. Antiphospholipid syndrome is known to cause RPL, and antenatal thromboprophylaxis reduces the risk of miscarriage. The evidence on alloimmune incompatibility as a cause of RPL is preliminary and no immunotherapy has been shown to be effective in the prevention of miscarriage. Recently a series of new factors that exhibit an association with RPL have been identified, and they might exhibit an additive or multiplicative effect on the RPL risk.
引用
收藏
页码:369 / 373
页数:5
相关论文
共 50 条
  • [31] ACCEPT Group Condensed Position Paper on the Management of Recurrent Pregnancy Loss
    Suker, Adriana
    Li, Ying
    Marren, Anthony
    Robson, Danielle
    AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 2025,
  • [32] TNF-α-positive patients with recurrent pregnancy loss: The etiology and management
    Cai, Zhuhua
    Guo, Xueke
    Zheng, Ge
    Xiang, Junmiao
    Liu, Lingyun
    Lin, Dongmei
    Deng, Xiaohui
    TECHNOLOGY AND HEALTH CARE, 2024, 32 (06) : 4581 - 4591
  • [33] Recurrent pregnancy loss: A review
    Timbers, KA
    Feinberg, RF
    NURSE PRACTITIONER FORUM-CURRENT TOPICS AND COMMUNICATIONS, 1997, 8 (02): : 77 - 88
  • [34] CHLAMYDIA AND RECURRENT PREGNANCY LOSS
    HARGER, JH
    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1993, 169 (02) : 434 - 435
  • [35] RECURRENT PREGNANCY LOSS - FOREWORD
    COULAM, CB
    CLINICAL OBSTETRICS AND GYNECOLOGY, 1986, 29 (04): : 863 - 864
  • [36] Immunotherapy for recurrent pregnancy loss
    Carp, Howard
    BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY, 2019, 60 : 77 - 86
  • [37] Recurrent pregnancy loss and thrombophilia
    Di Micco, Pierpaolo
    D'Uva, Maristella
    Strina, Ida
    De Placido, Giuseppe
    Di Fiore, Rosanna
    Quaranta, Sandro
    Castaldo, Giuseppe
    CLINICAL LABORATORY, 2007, 53 (5-6) : 309 - 314
  • [38] Recurrent pregnancy loss and thrombophilia
    Motha, M. B. C.
    Palihawadana, T. S.
    Perry, D. J.
    CEYLON MEDICAL JOURNAL, 2014, 59 (01) : 1 - 3
  • [39] Unexplained Recurrent Pregnancy Loss
    Saravelos, Sotirios H.
    Regan, Lesley
    OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA, 2014, 41 (01) : 157 - +
  • [40] Cytogenetics of recurrent pregnancy loss
    Nikitina, T. V.
    Lebedev, I. N.
    RUSSIAN JOURNAL OF GENETICS, 2014, 50 (05) : 435 - 446