THE H-1-NUCLEAR AND C-13-NUCLEAR MAGNETIC-RESONANCE SPECTRA OF MANZAMINE-C AND RELATED-COMPOUNDS

被引：0

作者：

SEKI, H ^{[1
]}

NAKAGAWA, M ^{[1
]}

HASHIMOTO, A ^{[1
]}

HINO, T ^{[1
]}

机构：

[1] CHIBA UNIV, FAC PHARMACEUT SCI, INAGE, CHIBA 263, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1993年 / 41卷 / 06期

关键词：

H-1-NMR; C-13-NMR; 2D-NMR; H-1-DETECTED HETERONUCLEAR MULTIPLE BOND CONNECTIVITY (HMBC); MANZAMINE-C; BETA-CARBOLINE;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The H-1- and C-13-NMR spectra of manzamine C (1) and its analogs (2-8) have been analyzed by applying HC-COSY (or HMQC) and COLOC (or HMBC) methods. The slow ring-inversion of the piperidine part in 6 was observed at room temperature. The free energy of activation for interconversion of rotamers in the amide analog (8) was evaluated.

引用

页码：1173 / 1176

页数：4

共 6 条

[1]

NAKAGAWA M, 1992, 112TH ANN M PHARM SO, P270

[2] MANZAMINE-B AND MANZAMINE-C, 2 NOVEL ALKALOIDS FROM THE SPONGE HALICLONA SP [J].

SAKAI, R ;

KOHMOTO, S ;

HIGA, T .

TETRAHEDRON LETTERS, 1987, 28 (45) :5493-5496

[3]

SEKI H, 1993, CHEM PHARM BULL, V41, P1169

[4] A TOTAL SYNTHESIS OF MANZAMINE-C [J].

TORISAWA, Y ;

HASHIMOTO, A ;

NAKAGAWA, M ;

HINO, T .

TETRAHEDRON LETTERS, 1989, 30 (47) :6549-6550

[5] A TOTAL SYNTHESIS OF MANZAMINE-C AND ITS GEOMETRICAL ISOMER [J].

TORISAWA, Y ;

HASHIMOTO, A ;

NAKAGAWA, M ;

SEKI, H ;

HARA, R ;

HINO, T .

TETRAHEDRON, 1991, 47 (38) :8067-8078

[6]

1987, HDB PROTON NMR SPECT

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