PROPAPAIN AND ITS CONVERSION TO PAPAIN - NEW TYPE OF ZYMOGEN ACTIVATION MECHANISM INVOLVING INTRAMOLECULAR THIOL-DISULFIDE INTERCHANGE

被引：40

作者：

BROCKLEHURST, K ^{[1
]}

KIERSTAN, MP ^{[1
]}

机构：

[1] UNIV LONDON, ST BARTHOLOMEWS HOSP, MED COLL, DEPT BIOCHEM & CHEM, LONDON EC1M 6BQ, ENGLAND

来源：

NATURE-NEW BIOLOGY | 1973年 / 242卷 / 119期

关键词：

D O I：

10.1038/newbio242167a0

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

收藏

页码：167 / 170

页数：4

相关论文

共 44 条

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[10] REACTIVITIES OF VARIOUS PROTONIC STATES IN REACTIONS OF PAPAIN AND OF L-CYSTEINE WITH 2,2'-DIPYRIDYL DISULFIDE AND WITH 4,4'-DIPYRIDYL DISULFIDE - EVIDENCE FOR NUCLEOPHILIC REACTIVITY IN UNIONIZED THIOL GROUP OF CYSTEINE-25 RESIDUE OF PAPAIN OCCASSIONED BY ITS INTERACTION WITH HISTIDINE-159-ASPARAGINE-175 HYDROGEN-BONDED SYSTEM
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