CA2+-ATPASE DISTRIBUTES DIFFERENTLY IN CARDIAC SARCOLEMMA THAN DIHYDROPYRIDINE RECEPTOR ALPHA-1 SUBUNIT AND NA+ CA2+ EXCHANGER

被引：14
|
作者：
IWATA, Y
HANADA, H
TAKAHASHI, M
SHIGEKAWA, M
机构：
[1] NATL CARDIOVASC CTR,RES INST,DEPT MOLEC PHYSIOL,SUITA,OSAKA 565,JAPAN
[2] MITSUBISHI KASEI INST LIFE SCI,MACHIDA,TOKYO 194,JAPAN
来源：
FEBS LETTERS | 1994年 / 355卷 / 01期
关键词：
SARCOLEMMAL CA2+-ATPASE; NA+/CA2+ EXCHANGER; DHP RECEPTOR ALPHA-1 SUBUNIT; CARDIAC MYOCYTE; HAMSTER HEART; CANINE HEART;
D O I：
10.1016/0014-5793(94)01174-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have investigated the distribution of the sarcolemmal Ca2+ transporters in hamster and dog ventricular myocytes by immunocytochemical and membrane fractionation techniques. The data suggest that the DHP receptor alpha 1 subunit and the Na+/Ca2+ exchanger are present in surface sarcolemma as well as T-tubule membranes located at the cardiac dyads. Compared with these Ca2+ transporters, the sarcolemmal Ca2+-ATPase is much less abundant in the latter fraction. Thus the sarcolemmal Ca2+-ATPase seems to be located predominantly in surface sarcolemma.
引用
收藏
页码：65 / 68
页数：4
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