X-RAY-INDUCED DNA DOUBLE-STRAND BREAKS AS LETHAL LESIONS IN DIPLOID HUMAN FIBROBLASTS COMPARED TO CHINESE-HAMSTER OVARY CELLS

被引：11
作者：
BAUMSTARKKHAN, C
机构：
[1] Radiologische Universitätsklinik, Experimentelle Radiologie und Strahlenbiologie, D-5300, Bonn 1
来源：
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1993年 / 63卷 / 03期
关键词：
D O I：
10.1080/09553009314550411
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Calibration of the non-denaturing (pH 9.6) filter elution technique by I-125 decays has been used to examine the relationship between X-ray-induced DNA double-strand breaks (dsb) and cellular survival of CHO cells and human fibroblasts. DNA dsb induction varies markedly between the two cell lines, reflecting the different survival levels. The relationships between lethal lesions (-1n S) and DNA dsb are also significantly different for CHO cells and human fibroblasts, suggesting either different probabilities of dsb conversion into lethal lesions or different repair capacities.
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页码：305 / 311
页数：7
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