Tumor Microenvironment in Head and Neck Squamous Cell Carcinomas

被引：6

作者：

Eskiizmir, Gorkem ^{[1
]}

机构：

[1] Celal Bayar Univ, Tip Fak, Kulak Burun Bogaz & Bas Boyun Cerrahisi Anabilim, Manisa, Turkey

来源：

TURKISH ARCHIVES OF OTORHINOLARYNGOLOGY | 2015年 / 53卷 / 03期

关键词：

Carcinoma; squamous cell of head and neck; head and neck neoplasms; tumor microenvironment;

D O I：

10.5152/tao.2015.1065

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Recent studies about solid tumors demonstrated that tumor microenvironment has an important role in tumor progression, aggressivity, and metastasis process, in addition to genetic aberrations and molecular alterations of cancer cells. Therefore, the crosstalks between cancerous and noncancerous cells and metabolic changes in tumor microenvironment cause significant detrimental effects. The purpose of this review is to present the role and effect of noncancerous cells and their crosstalks with cancer cells, metabolic changes in tumor microenvironment, and to discuss the clinical significance of all these factors with respect to the current literature.

引用

页码：120 / 127

页数：8

共 55 条

[1] Decreased NK Cells in Patients with Head and Neck Cancer Determined in Archival DNA [J].

Accomando, William P. ;

Wiencke, John K. ;

Houseman, E. Andres ;

Butler, Rondi A. ;

Zheng, Shichun ;

Nelson, Heather H. ;

Kelsey, Karl T. .

CLINICAL CANCER RESEARCH, 2012, 18 (22) :6147-6154

[2]

Argiris A, 2003, CANC TREAT, V114, P15

[3] Head and neck cancer [J].

Argiris, Athanassios ;

Karamouzis, Michalis V. ;

Raben, David ;

Ferris, Robert L. .

LANCET, 2008, 371 (9625) :1695-1709

[4] The tumor microenvironment at a glance [J].

Balkwill, Frances R. ;

Capasso, Melania ;

Hagemann, Thorsten .

JOURNAL OF CELL SCIENCE, 2012, 125 (23) :5591-5596

[5]

Balz V, 2003, CANCER RES, V63, P1188

[6]

Beasley NJP, 2002, CANCER RES, V62, P2493

[7]

Beasley NJP, 2001, CANCER RES, V61, P5262

[8] Regulatory T cells and their prognostic value for patients with squamous cell carcinoma of the head and neck [J].

Boucek, Jan ;

Mrkvan, Tomas ;

Chovanec, Martin ;

Kuchar, Martin ;

Betka, Jaroslav ;

Boucek, Vladimir ;

Hladikova, Marie ;

Betka, Jan ;

Eckschlager, Tomas ;

Rihova, Blanka .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2010, 14 (1-2) :426-433

[9] Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome [J].

Brizel, DM ;

Dodge, RK ;

Clough, RW ;

Dewhirst, MW .

RADIOTHERAPY AND ONCOLOGY, 1999, 53 (02) :113-117

[10] Tumor hypoxia at the micro-regional level: clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers [J].

Bussink, J ;

Kaanders, JHAM ;

van der Kogel, AJ .

RADIOTHERAPY AND ONCOLOGY, 2003, 67 (01) :3-15

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