STUDIES ON MECHANISM OF ACTION OF SALICYLATES .7. EFFECT OF A FEW ANTI-INFLAMMATORY AGENTS ON URIDINE-5'-DIPHOSPHOGLUCOSE DEHYDROGENASE

被引：11

作者：

LEE, KH

SPENCER, MR

机构：

[1] University of California, School of Pharmacy, San Francisco Medical Center, San Francisco, California

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 09期

关键词：

Salicylates–action mechanism; Uridine‐5′‐di‐ phosphoglucose dehydrogenase–anti‐inflamrnatory agents effect; UV spectrophotometry–analysis;

D O I：

10.1002/jps.2600580930

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Phenylbutazone, oxyphenbutazone, indomeihacin, flufenamic acid, and mefenamic acid, like salicylic acid, inhibit the oxidation of uridine‐5′‐diphosphoglucose (UDPG) competitively with nicotinamide adenosine dinucleotide (NAD) and noncompetitively with UDPG. The Km and Ki values of these inhibitory agents are presented. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1152 / &

共 8 条

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[3] LEE KH, 1969, J PHARM SCI, V58
[4] LEE KS, TO BE PUBLISHED
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[6] SMITH M. J. H., 1966, P49
[7] STROMINGER JL, 1957, J BIOL CHEM, V224, P79
[8] VONSCHONHOFER P, 1966, MED PHARMACOL EXPTL, V15, P491

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