ALPHA-METHYLENE AND GLYCIDIC ACID ANALOGS OF IPPA AS POTENTIAL MYOCARDIAL IMAGING AGENTS

被引：0

作者：

RUYAN, MK

BAKAN, DA

SKINNER, RWS

NEWMAN, C

GROSS, MD

COUNSELL, RE

机构：

[1] UNIV MICHIGAN,SCH MED,DEPT PHARMACOL,ANN ARBOR,MI 48109

[2] UNIV MICHIGAN,SCH MED,DEPT MED CHEM,ANN ARBOR,MI 48109

[3] VET ADM MED CTR,DEPT VET AFFAIRS,NUCL MED SERV,ANN ARBOR,MI 48104

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1995年 / 22卷 / 01期

关键词：

D O I：

10.1016/0969-8051(94)E0067-S

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Using organozinc cross-coupling reactions, two radiolabeled analogs of 15-(p-iodophenyl) pentadecanoic acid (IPPA) have been designed and synthesized as potential scintigraphic imaging agents for the heart. Both 15-(4-iodophenyl)-tridecylglycidic acid and 15-(4-iodophenyl)-2-methylene pentadecanoic acid were synthesized and radioiodinated. In tissue biodistribution studies in rats, only the alpha-methylene derivative of IPPA displayed a consistently higher heart to blood ratio and a substantially lower degree of thyroid accumulation than did IPPA alone. With respect to a scintigraphic imaging efficacy, the alpha-methylene analog of IPPA and IPPA itself showed essentially equivalent cardiac imaging profiles in rabbits, with a slight extension in imaging time for the alpha-methylene analog of IPPA.

引用

页码：95 / 103

页数：9

共 22 条

[1] SYNTHESIS OF FATTY-ACIDS USING ORGANOCOPPER(I) ATE COMPLEXES DERIVED FROM GRIGNARD-REAGENTS [J].