EFFECT OF LYSOPHOSPHATIDIC ACID ON THE PREIMPLANTATION DEVELOPMENT OF MOUSE EMBRYOS

被引:56
作者
KOBAYASHI, T [1 ]
YAMANO, S [1 ]
MURAYAMA, S [1 ]
ISHIKAWA, H [1 ]
TOKUMURA, A [1 ]
AONO, T [1 ]
机构
[1] UNIV TOKUSHIMA, FAC PHARMACEUT SCI, TOKUSHIMA 770, JAPAN
来源
FEBS LETTERS | 1994年 / 351卷 / 01期
关键词
EMBRYO; LYSOPHOSPHATIDIC ACID; PERTUSSIS TOXIN; MOUSE;
D O I
10.1016/0014-5793(94)00815-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effect of lysophosphatidic acid (LPA) on the preimplantation development of mouse embryos was examined. The blastocyst rates from 2-cell and 4-cell stage embryos were significantly higher in the presence of LPA at the pronuclear stage. However, the blastocyst rate from 4-cell stage embryos was significantly lower when LPA was added to the medium at the 4-cell stage than when it was added at the pronuclear stage. Furthermore, pretreatment of pronuclear stage embryos with pertussis toxin suppressed LPA-induced embryo development, suggesting that it is probably mediated by a Gi-protein-linked receptor.
引用
收藏
页码:38 / 40
页数:3
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