LIGAND-EXCHANGE REACTION OF SULFOXIDES IN ORGANIC-SYNTHESIS - A NEW METHOD FOR GENERATION OF MAGNESIUM ENOLATES OF ALPHA-CHLORO CARBOXYLIC-ACIDS AND THEIR DERIVATIVES

被引：10

作者：

SATOH, T ^{[1
]}

KITOH, Y ^{[1
]}

ONDA, K ^{[1
]}

YAMAKAWA, K ^{[1
]}

机构：

[1] SCI UNIV TOKYO,FAC PHARMACEUT SCI,ICHIGAYA FUNAGAWARA MACHI,SHINJUKU KU,TOKYO 162,JAPAN

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 14期

关键词：

SULFOXIDE; LIGAND EXCHANGE; MAGNESIUM ENOLATE; ALDOL REACTION; DARZEN REACTION;

D O I：

10.1016/S0040-4039(00)77606-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of alpha-chloro alpha-sulfinyl carboxylic acid derivatives with EtMgBr in THF at low temperature gave magnesium enolates of the alpha-chloro carboxylic acid derivatives. The enolates reacted with ketones and aldehydes to afford aldol compounds (or alpha,beta-epoxy acids) in good yields.

引用

页码：2331 / 2334

页数：4

共 24 条

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