RAPID APPEARANCE OF BETA-AMYLOID PRECURSOR PROTEIN IMMUNOREACTIVITY IN DAMAGED AXONS AND REACTIVE GLIAL-CELLS IN RAT-BRAIN FOLLOWING NEEDLE STAB INJURY

被引：148

作者：

OTSUKA, N ^{[1
]}

TOMONAGA, M ^{[1
]}

IKEDA, K ^{[1
]}

机构：

[1] TOKYO INST PSYCHIAT,DEPT ULTRASTRUCT & HISTOCHEM,TOKYO,JAPAN

来源：

BRAIN RESEARCH | 1991年 / 568卷 / 1-2期

关键词：

BETA-AMYLOID PRECURSOR PROTEIN; NEEDLE STAB INJURY; IMMUNOHISTOCHEMISTRY; ASTROCYTE; RAT BRAIN;

D O I：

10.1016/0006-8993(91)91422-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brains of rats that had received needle stab wounds were examined sequentially for 72 h by immunohistochemistry using antibodies to beta-amyloid precursor protein (APP). Immunoreactivity appeared 0.5 h after the injury in axons adjacent to the needle tract, becoming stronger over 15 h in neighboring swollen axons. APP-immunoreactive glial cells appeared 6 h after the injury around the needle tract and persisted throughout the experiment. Morphologically, these cells were thought to be mainly astrocytes.

引用

页码：335 / 338

页数：4

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