SYNTHESIS OF AN IODINE-125-LABELED RETINOID

被引：5
作者：
DAWSON, MI
HOBBS, PD
RHEE, SW
机构：
[1] SRI International, Menlo Park, California
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1992年 / 31卷 / 11期
关键词：
4-(5'; 6'; 7'; 8'-TETRAHYDRO-4'-[I-125]IODO-5'; 5'; 8'; 8'-TETRAMETHYL-2'-ANTHRACENYL)-BENZOIC ACID; 4'-[I-125]TTAB; ELECTROPHILIC DESTANNYLATION;
D O I：
10.1002/jlcr.2580311105
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The carrier-free synthesis of 4-(5',6',7',8'-tetrahydro-4'-[I-125]iodo-5', 5',8',8'-tetramethyl-2'-anthracenyl)benzoic acid (4'-[I-125]TTAB) is described. Site specific radioiodination was accomplished by electrophilic destannylation of the tri(n-butyl)tin analog of the retinoid with (NaI)-I-125 and chloramine-T. 4'-[I-125]TTAB (33 muCi, 1.65% radiochemical yield based on (NaI)-I-125 consumed) was purified by reversed-phase HPLC.
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页码：865 / 869
页数：5
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