TOBRAMYCIN PHARMACOKINETICS IN MORBIDLY OBESE PATIENTS

被引：57

作者：

BLOUIN, RA ^{[1
]}

MANN, HJ ^{[1
]}

GRIFFEN, WO ^{[1
]}

BAUER, LA ^{[1
]}

RECORD, KE ^{[1
]}

机构：

[1] UNIV KENTUCKY,MED CTR,COLL MED,DEPT SURG,LEXINGTON,KY 40536

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 1979年 / 26卷 / 04期

关键词：

D O I：

10.1002/cpt1979264508

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tobramycin kinetics were examined in 9 morbidly obese women following a single intavenous (120 mg) bolus. After the injection, serum elimination conformed to a 2-compartment open model with a and β t 1 2s of 0.285 and 2.1 hr. The volume of distribution (Varea was determined to be 0.44 1/kg ideal body weight (IBW) and 0.20 1/kg total body weight (TBW). To normalize Varea to 0.26 1/kg, 58% of the patients' adipose weight (TBW - IBW) must also be taken into account. © 1979.

引用

页码：508 / 512

页数：5

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