The comparative value of pleural fluid adenosine deaminase and neopterin levels in diagnostic utility of pleural tuberculosis

被引:7
作者
Kosar, Filiz [1 ]
Yurt, Sibel [1 ]
Yigitbas, Burcu Arpinar [1 ]
Seker, Baris [1 ]
Ozcelik, Hatice Kutbay [2 ]
Uzun, Hafize [3 ]
机构
[1] Yedikule Chest Dis & Chest Surg Training & Res Ho, Clin Chest Dis, Istanbul, Turkey
[2] Bezmialem Vakif Univ, Fac Med, Dept Chest Dis, Istanbul, Turkey
[3] Istanbul Univ, Fac Cerrahpasa Med, Dept Biochem, Istanbul, Turkey
来源
TUBERKULOZ VE TORAK-TUBERCULOSIS AND THORAX | 2015年 / 63卷 / 04期
关键词
Adenosine deaminase; neopterin; pleural tuberculosis; pleural effusion;
D O I
10.5578/tt.9973
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Introduction: The aim of the present study was to evaluate and compare the diagnostic accuracy of pleura levels of adenosinedeaminase (ADA) and neopterin for the differential diagnosis of pleural tuberculosis (TP). Patients and Methods: The study included 50 patients with TB, 27 patients with malignancies, and 24 patients with pleural effusion of non-tuberculous and non-malignant origin as controls. ADA and neopterin levels in pleural fluid were measured by spectrofotometric and ELISA method, respectively. Results: Pleural neopterin levels were significantly higher in patients with pleural TB than patients with malignancy (p<0.001). Pleural ADA levels were significantly higher in patients with pleural TB than patients with malignancy (p<0.001) and patients with benign non-tuberculosis effusions (p<0.001). The mean levels of ADA and neopterin in pleural effusion were evaluated according to their underlying diseases for the diagnostic accuracy. As for pleural TB receiving operating characteristic curves identified the following results; The best cut-off value for pleural neopterin was 4.7 U/L and yielded a sensitivity and specificity of 86% and 72.55%, respectively. Taking a cut-off value of 42 U/L for pleural ADA, the sensitivity and the specificity were found to be 88% and 68.63%, respectively. Conclusions: In the diagnosis of pleural TB pleural neopterin level has a comparable sensitivity to pleural ADA activity. Both markers may find a place as a routine investigation in the coming days for early detection of TB. However, these tests should not be considered an alternative to biopsy and culture.
引用
收藏
页码:243 / 249
页数:7
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