LIPID-PEROXIDATION AND ANTIOXIDANT ENZYMES IN VANADATE-TREATED RATS

被引：34

作者：

RUSSANOV, E ^{[1
]}

ZAPOROWSKA, H ^{[1
]}

IVANCHEVA, E ^{[1
]}

KIRKOVA, M ^{[1
]}

KONSTANTINOVA, S ^{[1
]}

机构：

[1] MARIE CURIE SKLODOWSKA UNIV,INST BIOL,DEPT CELL BIOL,PL-20033 LUBLIN,POLAND

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1994年 / 107卷 / 03期

关键词：

LIPID PEROXIDATION; ANTIOXIDANT ENZYMES; VANADATE; ERYTHROCYTE COUNT;

D O I：

10.1016/1367-8280(94)90070-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Male Wistar rats received an aqueous solution of ammonium metavanadate (AMV) of 0.15 mg/V/ml concentration instead of water for 14 days. The erythrocyte count and haemoglobin level in blood were not changed; the haematocrit index was slightly increased. The spontaneous lipid peroxidation in kidney and liver homogenates was increased. The Fe(II)- or ascorbate-induced lipid peroxidation was more pronounced in the kidney than in the liver. No changes in lipid peroxidation were observed in erythrocytes after AMV treatment. The AMV treatment resulted in a decrease in the activity of the antioxidant enzymes, catalase and glutathione peroxidase in the kidney and liver; the cytosolic Cu,Zn-SOD and mitochondrial Mn-SOD were unchanged. The activity of the enzymes in blood was not changed. The results are discussed with a view to the participation of lipid peroxidation in vanadium toxicity.

引用

页码：415 / 421

页数：7

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