NONKETOTIC HYPERGLYCINEMIA - CLINICAL AND ELECTROPHYSIOLOGIC EFFECTS OF DEXTROMETHORPHAN, AN ANTAGONIST OF THE NMDA RECEPTOR

被引：49
作者：
SCHMITT, B
STEINMANN, B
GITZELMANN, R
THUNHOHENSTEIN, L
MASCHER, H
DUMERMUTH, G
机构：
[1] UNIV ZURICH,CHILDRENS HOSP,DIV METAB,CH-8032 ZURICH,SWITZERLAND
[2] UNIV ZURICH,CHILDRENS HOSP,DIV NEUROL,CH-8032 ZURICH,SWITZERLAND
来源：
NEUROLOGY | 1993年 / 43卷 / 02期
关键词：
D O I：
10.1212/WNL.43.2.421
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A 10-week-old girl with nonketotic hyperglycinemia was treated with increasing amounts of dextromethorphan, an NMDA receptor antagonist. She improved neurologically; at 35 mg/kg/d, seizures ceased and EEG normalized. Dextromethorphan withdrawal resulted in a dramatic clinical deterioration coinciding with epileptic and high-voltage slow activity in the EEG. After reintroduction of dextromethorphan (35 mg/kg/d), recovery occurred within 24 hours.
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收藏
页码：421 / 424
页数：4
相关论文
共 10 条
[1]   KINETIC-ANALYSIS OF ANTAGONIST ACTION AT N-METHYL-D-ASPARTIC ACID RECEPTORS - 2 BINDING-SITES EACH FOR GLUTAMATE AND GLYCINE [J].
BENVENISTE, M ;
MAYER, ML .
BIOPHYSICAL JOURNAL, 1991, 59 (03) :560-573
[2]  
CHOI DW, 1987, J PHARMACOL EXP THER, V242, P713
[3]  
CHOI DW, 1991, EXCITATORY AMINO ACI, P216
[4]  
Gitzelmann R., 1977, Helvetica Paediatrica Acta, V32, P517
[5]  
HAMOSH A, 1990, AM J HUM GENET, V47, pA157
[6]   HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF DEXTRORPHAN AND 3-HYDROXYMORPHINAN IN HUMAN-PLASMA BASED ON A SELECTIVE PRECOLUMN SAMPLE CLEANUP [J].
MASCHER, H .
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1987, 420 (01) :217-222
[7]  
Nyhan W.L., 1989, METABOLIC BASIS INHE, P743
[8]   NONKETOTIC HYPERGLYCINEMIA - TREATMENT WITH NMDA ANTAGONIST AND CONSIDERATION OF NEUROPATHOGENESIS [J].
OHYA, Y ;
OCHI, N ;
MIZUTANI, N ;
HAYAKAWA, C ;
WATANABE, K .
PEDIATRIC NEUROLOGY, 1991, 7 (01) :65-68
[9]  
PRESS GA, 1989, AM J NEURORADIOL, V10, P315
[10]   DEXTROMETHORPHAN AND NEUROMODULATION - OLD DRUG COUGHS UP NEW ACTIVITIES [J].
TORTELLA, FC ;
PELLICANO, M ;
BOWERY, NG .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, 10 (12) :501-507
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