GLIAL FIBRILLARY TANGLES WITH STRAIGHT TUBULES IN THE BRAINS OF PATIENTS WITH PROGRESSIVE SUPRANUCLEAR PALSY

被引：113
作者：
NISHIMURA, M
NAMBA, Y
IKEDA, K
ODA, M
机构：
[1] TOKYO METROPOLITAN NEUROL HOSP,DEPT NEUROL,TOKYO,JAPAN
[2] TOKYO METROPOLITAN NEUROL HOSP,DEPT NEUROPATHOL,TOKYO,JAPAN
[3] UNIV TOKYO,FAC MED,INST BRAIN RES,DEPT NEUROPATHOL,TOKYO 113,JAPAN
[4] TOKYO INST PSYCHIAT,DEPT ULTRASTRUCT & HISTOCHEM,TOKYO,JAPAN
来源：
NEUROSCIENCE LETTERS | 1992年 / 143卷 / 1-2期
关键词：
STRAIGHT TUBULE; GLIAL TANGLE; TAU PROTEIN; PROGRESSIVE SUPRANUCLEAR PALSY; NEUROFIBRILLARY TANGLE; IMMUNOHISTOCHEMISTRY;
D O I：
10.1016/0304-3940(92)90227-X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A recent report has described the appearance of silver positive, tau-immunoreactive astrocytes in the brains of patients with progressive supranuclear palsy (PSP) (Neurosci. Lett., 135 (1992) 99 102). In this study we confirmed this finding in two cases of PSP by using Bodian silver staining and immunohistochemistry with antibody to human tau protein. By electron microscopy we demonstrated that fibrillary masses present in these unique astrocytes were made up of straight tubules that were indistinguishable from those of neurofibrillary tangles of PSP. The term `glial fibrillary tangle' was proposed for these structures.
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页码：35 / 38
页数：4
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