ORGANIZATION OF THE HUMAN MONOAMINE-OXIDASE GENES AND LONG-RANGE PHYSICAL MAPPING AROUND THEM

被引：64
作者：
CHEN, ZY
POWELL, JF
HSU, YPP
BREAKEFIELD, XO
CRAIG, IW
机构：
[1] HARVARD UNIV, SCH MED, NEUROSCI PROGRAM, BOSTON, MA 02115 USA
[2] VET ADM MED CTR W ROXBURY, RES SERV, BOSTON, MA 02132 USA
[3] INST PSYCHIAT, DEPT NEUROSCI, LONDON SE5 8AF, ENGLAND
[4] MASSACHUSETTS GEN HOSP, CTR NEUROSCI, BOSTON, MA 02114 USA
来源：
GENOMICS | 1992年 / 14卷 / 01期
关键词：
D O I：
10.1016/S0888-7543(05)80286-1
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A 265-kb yeast artificial chromosome containing sequences for human monoamine oxidase A and B (MAO-A and MAO-B) genes has been characterized. These two genes are localized within a region of about 240 kb and are arranged in a tail-to-tail configuration, with the 3′ coding sequences separated by about 50 kb. A region about 2.5 Mb around the MAO loci was mapped by pulsed-field gel electrophoresis (PFGE). Comparisons between the restriction maps derived from the YAC and the long-range map derived from genomic digestions were in general agreement. The important features identified include a CpG island at the 5′ end of the MAO-A and MAO-B genes, respectively. The combined information supports the order of markers within this region to be DXS77-DXS7-MAOA-MAOB. © 1992 Academic Press, Inc. All rights reserved.
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页码：75 / 82
页数：8
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