PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY IN HIV-1-INFECTED CHILDREN

被引:63
作者
BERGER, JR
SCOTT, G
ALBRECHT, J
BELMAN, AL
TORNATORE, C
MAJOR, EO
机构
[1] NINCDS,BETHESDA,MD 20892
[2] SUNY STONY BROOK,DEPT NEUROL,STONY BROOK,NY 11794
[3] UNIV MIAMI,SCH MED,DEPT PEDIAT,MIAMI,FL 33136
关键词
AIDS; HIV-1; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; JC VIRUS; CHILDREN;
D O I
10.1097/00002030-199208000-00012
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objective: To describe the clinical and pathologic features of two HIV-1-infected children with progressive multifocal leukoencephalopathy (PML). Design: Case report. Setting: University-affiliated, public-health trust hospital. Methods: Two HIV-1-infected children with PML are described. A 13-year-old girl, presumed to be congenitally infected with HIV-1, presented with dysarthria and paresthesias of the tongue and chin that evolved rapidly to dementia, muteness and severe spastic quadriparesis. The other patient, a 10-year-old boy who developed HIV-1 infection from a blood transfusion at the age of 3 years, presented with a facial palsy with subsequent development of right hemiparesis and aphasia. Results: Brain biopsy in the first child and autopsy in the second confirmed the diagnosis of PML. In both patients, the CD4 T-lymphocyte count was < 100 x 10(6)/l at the time of neurological presentation. Conclusion: Despite seroepidemiological studies suggesting that the majority of individuals are infected with JC virus during childhood, PML is rare in children with impaired cell-mediated immunity. Our patients illustrate that PML is among the neurological complications of HIV-1 infection in children.
引用
收藏
页码:837 / 841
页数:5
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