The first enantiocontrolled total synthesis of (-)-goniomitine, a new structural type of indole alkaloid of the Aspidosperma family isolated from the root bark of Gonioma malagasy, has been completed starting from a chiral cyclopentadienone synthon and establishes the absolute stereochemistry as 20R, 21S.
机构:
Evans Chemical Laboratories, Ohio State University, Columbus, OH 43210, United StatesEvans Chemical Laboratories, Ohio State University, Columbus, OH 43210, United States
Paquette, Leo A.
Boulet, Serge L.
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机构:
Evans Chemical Laboratories, Ohio State University, Columbus, OH 43210, United StatesEvans Chemical Laboratories, Ohio State University, Columbus, OH 43210, United States