METALLOTHIONEIN INDUCTION AND METAL HOMEOSTASIS IN RAINBOW-TROUT HEPATOCYTES EXPOSED TO MERCURY

被引：4
|
作者：
GAGNE, F
MARION, M
DENIZEAU, F
机构：
[1] UNIV QUEBEC, DEPT CHIM, CASIER POSTAL 8888, SUCC A, MONTREAL H3C 3P8, QUEBEC, CANADA
[2] UNIV QUEBEC, DEPT CHIM, CASIER POSTAL 8888, SUCC A, MONTREAL H3C 3P8, QUEBEC, CANADA
来源：
TOXICOLOGY LETTERS | 1990年 / 51卷 / 01期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Hepatocytes; Mercury; Metal homeostasis; Metallothionein;
D O I：
10.1016/0378-4274(90)90229-F
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Rainbow trout hepatocytes were exposed to a sublethal concentration of mercury (Hg) (100 nM) for 0, 5, 10, 15, 20, 25, 30 and 35 h at 15°C. The hepatocytes were found to accumulate appreciable quantities of Hg. The presence of Hg led to elevated Ca, Cu and Zn levels in cells. Hg was bound mainly to lowmolecular-weight components, although it induced the synthesis of metallothionein (MT). The results suggest that when hepatocytes are exposed to low levels of Hg, MT does not play a significant role in the sequestration of the metal. The elevated cellular Cu and Zn levels could be associated with the induction of MT. © 1990.
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页码：99 / 107
页数：9
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