INTERLEUKIN-10 MESSENGER-RIBONUCLEIC-ACID IN HUMAN PLACENTA - IMPLICATIONS OF A ROLE FOR INTERLEUKIN-10 IN FETAL ALLOGRAFT PROTECTION

被引:74
作者
CADET, P
RADY, PL
TYRING, SK
YANDELL, RB
HUGHES, TK
机构
[1] UNIV TEXAS,MED BRANCH,DEPT MICROBIOL & IMMUNOL,GALVESTON,TX 77555
[2] UNIV TEXAS,MED BRANCH,DEPT DERMATOL,GALVESTON,TX 77555
[3] UNIV TEXAS,MED BRANCH,DEPT OBSTET & GYNECOL,GALVESTON,TX 77555
关键词
INTERLEUKIN-10; FETAL ALLOGRAFT; PLACENTA;
D O I
10.1016/0002-9378(95)90164-7
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: Our purpose was to determine whether interleukin-10 is expressed in human placental tissue, which might imply a role for it in fetal allograft protection. STUDY DESIGN: Detection of interleukin-10 messenger ribonucleic acid in human placental tissue and in human placental JAR cells by reverse transcription-coupled polymerase chain reaction was studied. RESULTS: Interleukin-10 messenger ribonucleic acid was detected in human placental tissue from term mothers and in human placental JAR cells. Sequence analysis of the expected interleukin-10 complementary deoxyribonucleic acid fragment revealed 100% homology to authentic interleukin-10 complementary deoxyribonucleic acid. CONCLUSION: Our results indicated that human placental tissue from term mothers expressed high levels of interleukin-10 messenger ribonucleic acid, suggesting that cells that produce interleukin-10 and that are associated with the placenta may play a role in preventing rejection of the fetal allograft by the mother.
引用
收藏
页码:25 / 29
页数:5
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