A Challenging Case of Severe Ulcerative Colitis following the Initiation of Secukinumab for Ankylosing Spondylitis

被引：34

作者：

Ehrlich, Dean ^{[1
]}

Jamaluddin, Nimah ^{[1
]}

Pisegna, Joseph ^{[1
,2
]}

Padua, David ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Digest Dis, Los Angeles, CA 90095 USA

[2] VA Greater Los Angeles Healthcare Syst, Div Gastroenterol Hepatol & Parenteral Nutr, Los Angeles, CA 90073 USA

来源：

CASE REPORTS IN GASTROINTESTINAL MEDICINE | 2018年 / 2018卷

关键词：

D O I：

10.1155/2018/9679287

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Secukinumab is an interleukin-17 inhibitor used for the treatment of ankylosing spondylitis (AS), psoriasis, and psoriatic arthritis. The risk of exacerbating underlying inflammatory bowel disease (IBD) in patients being treated with secukinumab for other conditions is controversial. We document a patient with AS and previously undiagnosed IBD, found to be in a severe ulcerative colitis flare shortly after receiving the loading dose of secukinumab. There are no guidelines regarding biologic salvage therapy for IBD in the setting of active treatment with another biologic agent. After waiting one half-life of secukinumab, our patient had an excellent response to initiation of infliximab.

引用

页数：4

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