INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR FUNCTION IN NEONATAL CARDIOMYOCYTES

被引：5

作者：

FITZGERALD, M ^{[1
]}

ANDERSON, KE ^{[1
]}

WOODCOCK, EA ^{[1
]}

机构：

[1] BAKER MED RES INST,CELL BIOCHEM LAB,PRAHRAN,VIC 3141,AUSTRALIA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1994年 / 268卷 / 02期

关键词：

INOSITOL 1,4,5-TRISPHOSPHATE; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; HEART; RAT; CA2+ RELEASE; NEONATAL CARDIOMYOCYTE;

D O I：

10.1016/0922-4106(94)90200-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have previously reported that the metabolism of inositol(1,4,5)tris phosphate (Ins(1,4,5)P-3)is altered when rat neonatal ventricular cardiomyocytes are isolated and cultured. In the current study we show that the mass content of Ins(1,4,5)P-3 is lower in the isolated cells than in the intact tissue. However, the properties of the Ins(1,4,5)P-3 receptors were not different in the two preparations and the isolated cells remained insensitive to Ins(1,4,5)P-3 in terms of Ca-45(2+) release. Thus, despite the altered pattern of metabolism of Ins(1,4,5)P-3 in isolated neonatal cells, the properties of the receptors were similar to those reported in other myocardial preparations.

引用

页码：275 / 278

页数：4

共 46 条

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