STRUCTURE OF MALOLACTOMYCIN-A AND MALOLACTOMYCIN-B, NOVEL 40-MEMBERED MACROLIDE ANTIBIOTICS

被引：20

作者：

KOSHINO, H

KOBINATA, K

UZAWA, J

URAMOTO, M

ISONO, K

OSADA, H

机构：

[1] TOKAI UNIV,SCH MARINE SCI & TECHNOL,DEPT MARINE SCI,SHIMIZU,SHIZUOKA 424,JAPAN

[2] RIKEN,ANTIBIOT LAB,WAKO,SAITAMA 35101,JAPAN

来源：

TETRAHEDRON | 1993年 / 49卷 / 39期

关键词：

D O I：

10.1016/S0040-4020(01)81903-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Malolactomycins A and B are novel 40-membered polyol macrolide antifungal antibiotics which have hemiacetal, malonate and dimethylguanidyl groups. Malolactomycins A and B are positional isomers of malonate and interconvertible each other by transesterification. The structures of malolactomycins A and B have been determined by spectroscopic analyses, especially NMR for the parent antibiotics and MS for the oxidative product.

引用

页码：8827 / 8836

页数：10

共 15 条

[1] ISOLATION OF NEOCOPIAMYCIN A FROM STREPTOMYCES-HYGROSCOPICUS VAR CRYSTALLOGENES, THE COPIAMYCIN SOURCE [J].