RELEASE MECHANISMS IN GELFORMING SUSTAINED-RELEASE PREPARATIONS

被引：190

作者：

BAMBA, M

PUISIEUX, F

MARTY, JP

CARSTENSEN, JT

机构：

[1] Laboratoire Galenique, Faculte de Pharmacie, Universite de Paris-Sud

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1979年 / 2卷 / 5-6期

关键词：

D O I：

10.1016/0378-5173(79)90037-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A system consisting of quinidine sulfate, excipient and gum (in various concentrations) was tested in tablet form. The insensitivity of this system to (a) the nature of the excipient and (b) the pH of the dissolution liquid is noted. The release mechanism is established as being limited by the rate of water penetration and back diffusion of the dissolved substance, whereas gelation rates and actual dissolution rate of the drug are not rate determining. © 1979.

引用

页码：307 / 315

页数：9

共 11 条

[1]

BENNETT CA, 1954, STATISTICAL ANAL CHE, P222

[2]

CARSTENSEN JT, 1977, PHARM SOLIDS SOLID D, P173

[3]

CARSTENSEN JT, 1973, THEORY PHARMACEUTICA, V1, P219

[4] INFLUENCE OF SHAPE FACTORS ON KINETICS OF DRUG RELEASE FROM MATRIX TABLETS .1. THEORETICAL [J].