INTERACTION OF DIMETHYL PROSTAGLANDIN-E2 AND ETHANOL ON PANCREATIC-SECRETION OF RAT

The authors studied the action of 16,16-dimethyl prostaglandin E2 methyl ester (DiMePGE2) on pancreatic secretion in the unanesthetized rat with pancreatic and duodenal fistulae. DiMePGE2 inhibited volume, protein secretion, and bicarbonate output. The inhibition of protein concentration is dose related (ED50 = 5.35 μg/rat). DiMePGE2 was effective by the intraduodenal, intravenous, and intraperitoneal routes. Intraduodenal infusion of ethanol alone (2 mL 16% (v/v) in 1 hr) strongly increased protein secretion (concentration, +30%; output, +69%). When 4 μg DiMePGE2 was injected intraperitoneally just before the ethanol infusion, the secretory effect of ethanol disappeared and the inhibition was similar to that observed with DiMePGE2 alone.