NEW METHODOLOGY FOR CALCULATION OF ACID-BASE DISSOCIATION-CONSTANTS OF MONOPROTIC AND DIPROTIC ACIDS WITH CLOSE PK VALUES FROM ABSORPTIOMETRIC DATA AND PH MEASUREMENTS

A new methodology for calculation of acid-base dissociation constants of monoprotic and diprotic compounds from absorptiometric data and pH measurements was developed. The equations derived for monoprotic compounds enable calculation of their pK Values even in those cases where the molar absorptivities of the acid or basic species involved are unknown; those for diprotic compounds allow the easy calculation of acid-base dissociation constants however similar they may be. The applicability and limitations of the proposed methodology were studied in simulated processes. Finally, the new methodology was used to calculate the acid-base dissociation constant for maleimide dioxime at several wavelengths and with goad results.