STRUCTURES OF COMPLEXES OF COBALT(III) AND GLUCOSAMINE - APPLICATIONS OF MOLECULAR MECHANICS AND NMR-SPECTROSCOPY

被引：17

作者：

BUNEL, S ^{[1
]}

IBARRA, C ^{[1
]}

MORAGA, E ^{[1
]}

BLASKO, A ^{[1
]}

BUNTON, CA ^{[1
]}

机构：

[1] UNIV CALIF SANTA BARBARA,DEPT CHEM,SANTA BARBARA,CA 93106

来源：

CARBOHYDRATE RESEARCH | 1993年 / 244卷 / 01期

关键词：

D O I：

10.1016/0008-6215(93)80001-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The H-1 NMR signals of the hydrochlorides of 2-amino-2-deoxy-alpha- and -beta-D-glucose (alpha- and beta-D-glucosamine) have been assigned and chemical shifts and coupling constants determined from their phase-sensitive COSY spectra in D2O. Based on the Karplus relation the observed coupling constants fit H-H dihedral angles calculated with MM2 parameters. The COSY spectrum of the LAMBDA isomer of [Co(en)2-D-glucosamine]2+ shows that it is formed from the alpha anomer. The coupling constants, except for J2,3 and J3,4 agree qualitatively with dihedral angles predicted by MM2 parameters. The structure of triammine-Co(III)-L-malate simulated by using MM2 parameters agrees reasonably well with that from X-ray crystallography.

引用

页码：1 / 14

页数：14

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