HETERO-RING LITHIATION OF N-METHYL-4-QUINOLONE AND N-METHYLQUINOLINE-4-THIONE

被引：17

作者：

ALVAREZ, M

SALAS, M

RIGAT, L

DEVECIANA, A

JOULE, JA

机构：

[1] UNIV BARCELONA,FAC PHARM,ORGAN CHEM LAB,E-08028 BARCELONA,SPAIN

[2] UNIV MANCHESTER,DEPT CHEM,MANCHESTER M13 9PL,LANCS,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 03期

关键词：

D O I：

10.1039/p19920000351

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lithiation of 1-methyl-4-quinolone and 1-methylquinoline-4-thione with lithium diisopropylamide (LDA) at -78-degrees-C takes place at C-2. The resulting lithio-species react with a variety of electrophiles to give 2-substituted-4-quinolones and -quinolines-4-thiones respectively. 1-Methylquinoline-4-thione is easily converted into 1-methyl-4-quinolone in protic solution.

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页码：351 / 356

页数：6

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