PHARMACOLOGICAL EFFECTS OF PHENYLPROPANOID GLYCOSIDES FROM OROBANCHE-HEDERAE

被引：22

作者：

PIERETTI, S

DIGIANNUARIO, A

CAPASSO, A

NICOLETTI, M

机构：

[1] NAPLES UNIV, DIPARTIMENTO FARMACOL SPERIMENTALE, I-80138 NAPLES, ITALY

[2] UNIV ROME LA SAPIENZA, DEPT BIOL VEGETALE, I-00185 ROME, ITALY

来源：

PHYTOTHERAPY RESEARCH | 1992年 / 6卷 / 02期

关键词：

PHENYLPROPANOID GLYCOSIDES; OROBANCHE-HEDERAE; PHARMACOLOGY; CENTRAL NERVOUS SYSTEM;

D O I：

10.1002/ptr.2650060208

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A purified extract of Orobanche hederae, composed of two phenylpropanoid glycosides, verbascoside and orobanchoside (55:45), was investigated for its pharmacological profile. The extract did not exert significant changes on the nociceptive threshold in the hot plate test; no effect was registered on guinea-pig ileum. On the other hand, the phenylpropanoid glycoside mixture significantly prolonged sleep induced by pentobarbital and affected locomotor activity in mice; it also produced a slowing of the electroencephalographic trace and induced, when injected in the lateral cerebral ventricle, epileptiform activity in male rabbits. These effects may suggest neuroleptic-like properties.

引用

页码：89 / 93

页数：5

共 27 条

[1] EEG AND BEHAVIORAL-EFFECTS OF MORPHINE, ENKEPHALINS AND DERIVATIVES ADMINISTERED INTO THE LATERAL CEREBRAL-VENTRICLES OF RATS AND RABBITS [J].

ALOISI, F ;

SCOTTIDECAROLIS, A ;

LONGO, V .

PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 1980, 12 (05) :467-478

[2]

ANDARY C, 1988, Plantes Medicinales et Phytotherapie, V22, P17

[3]

ANDARY C, 1980, FARMACO-ED SCI, V35, P3

[4]

Baldessarini RJ, 1985, PHARMACOL BASIS THER, P387

[5] PHARMACOLOGICAL EFFECTS OF 3 PHENYLPROPANOID GLYCOSIDES FROM MUSSATIA [J].

CANO, E ;

VEIGA, M ;

JIMENEZ, C ;

RIGUERA, R .

PLANTA MEDICA, 1990, 56 (01) :24-26

[6]

CAPASSO A, 1988, ACTA THERAP, V14, P249

[7] MYRICOSIDE, AN AFRICAN ARMYWORM ANTIFEEDANT - SEPARATION BY DROPLET COUNTERCURRENT CHROMATOGRAPHY [J].

COOPER, R ;

SOLOMON, PH ;

KUBO, I ;

NAKANISHI, K ;

SHOOLERY, JN ;

OCCOLOWITZ, JL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (27) :7953-7955

[8]

EDDY NB, 1953, J PHARMACOL EXP THER, V107, P385

[9]

EHRENPREIS S, 1972, DRUG ADDICTION EXPT, P319

[10]

ENDO K, 1982, HETEROCYCLES, V19, P261

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