CDNA ISOLATION, EXPRESSION ANALYSIS, AND CHROMOSOMAL LOCALIZATION OF 2 HUMAN ZINC FINGER GENES

被引：50

作者：

LANIA, L ^{[1
]}

DONTI, E ^{[1
]}

PANNUTI, A ^{[1
]}

PASCUCCI, A ^{[1
]}

PENGUE, G ^{[1
]}

FELICIELLO, I ^{[1
]}

LAMANTIA, G ^{[1
]}

LANFRANCONE, L ^{[1
]}

PELICCI, PG ^{[1
]}

机构：

[1] UNIV PERUGIA,INST MED CLIN 1,I-06100 PERUGIA,ITALY

来源：

GENOMICS | 1990年 / 6卷 / 02期

关键词：

D O I：

10.1016/0888-7543(90)90574-E

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

On the basis of sequence similarity in the repeated zinc finger domain, we have identified and characterized two human cDNA clones (ZNF7 and ZNF8), both encoding proteins containing potential finger-like nucleic acid binding motifs. Northern blot analysis indicates that both genes are expressed as multiple transcripts and they are ubiquitously present in many human cell lines of different embryological derivation. Moreover, their expression is modulated during in vitro induced terminal differentiation of human myeloid cell line HL-60. By in situ hybridization experiments, we have localized the ZNF7 gene to chromosome 8 (region q24) and the ZNF8 gene to the terminal band of the long arm of chromosome 20 (20q13). © 1990.

引用

页码：333 / 340

页数：8

共 34 条

[1] XFIN - AN EMBRYONIC GENE ENCODING A MULTIFINGERED PROTEIN IN XENOPUS [J].