REDUCED GONADOTROPIN-SECRETION IN POST-MENOPAUSAL WOMEN DURING TREATMENT WITH A STIMULATORY LRH ANALOG

被引：68

作者：

BERGQUIST, C ^{[1
]}

NILLIUS, SJ ^{[1
]}

WIDE, L ^{[1
]}

机构：

[1] UNIV UPPSALA HOSP, DEPT CLIN CHEM, S-75014 UPPSALA, SWEDEN

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1979年 / 49卷 / 03期

关键词：

D O I：

10.1210/jcem-49-3-472

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The potent and long-acting LRH agonist D-Ser(TBU)6-EA10-LRH was administered in a daily subcutaneous dose of 5 μg to 5 postmenopausal women for a period of 10 days. The LRH analogue produced a significant decrease in both the basal FSH and LH levels and the gonadotropin responses to the agonist. The estrogen levels in serum remained unchanged during the study period. The results suggest that D-Ser(TBU)6-EA10-LRH has a direct inhibitory effect at the pituitary level. © 1979 by The Endocrine Society.

引用

页码：472 / 474

页数：3

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