REDUCED GONADOTROPIN-SECRETION IN POST-MENOPAUSAL WOMEN DURING TREATMENT WITH A STIMULATORY LRH ANALOG

被引：68

作者：

BERGQUIST, C ^{[1
]}

NILLIUS, SJ ^{[1
]}

WIDE, L ^{[1
]}

机构：

[1] UNIV UPPSALA HOSP, DEPT CLIN CHEM, S-75014 UPPSALA, SWEDEN

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1979年 / 49卷 / 03期

关键词：

D O I：

10.1210/jcem-49-3-472

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The potent and long-acting LRH agonist D-Ser(TBU)6-EA10-LRH was administered in a daily subcutaneous dose of 5 μg to 5 postmenopausal women for a period of 10 days. The LRH analogue produced a significant decrease in both the basal FSH and LH levels and the gonadotropin responses to the agonist. The estrogen levels in serum remained unchanged during the study period. The results suggest that D-Ser(TBU)6-EA10-LRH has a direct inhibitory effect at the pituitary level. © 1979 by The Endocrine Society.

引用

页码：472 / 474

页数：3

共 16 条

[1] HYPOPHYSEAL RESPONSES TO CONTINUOUS AND INTERMITTENT DELIVERY OF HYPOTHALAMIC GONADOTROPIN-RELEASING HORMONE
BELCHETZ, PE
PLANT, TM
NAKAI, Y
KEOGH, EJ
KNOBIL, E
[J]. SCIENCE, 1978, 202 (4368) : 631 - 633
[2] BERGQUIST C, CONTRACEPTION
[3] EFFECT OF D-SER (TBU)6-LH-RH-EA10 UPON GONADOTROPIN RELEASE IN NORMALLY CYCLIC WOMEN
DERICKSTAN, JSE
HAMMER, E
TAUBERT, HD
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1977, 45 (03) : 597 - 600
[4] HANKER JP, 1978, ACTA ENDOCRINOL-COP, V89, P625
[5] TIME COURSE OF SERUM ESTROGEN AND LUTEINIZING HORMONE (LH) CONCENTRATIONS DURING MENSTRUAL CYCLE OF RHESUS MONKEY
HOTCHKIS.J
ATKINSON, LE
KNOBIL, E
[J]. ENDOCRINOLOGY, 1971, 89 (01) : 177 - &
[6] JEWELEWICZ R, 1974, EUR J OBSTET GYN R B, V4, P175
[7] ACUTE EFFECTS OF A NEW STIMULATORY LUTEINIZING-HORMONE-RELEASING HORMONE ANALOG D-SER(TBU)6-EA10-LRH ON GONADOTROPIN AND GONADAL STEROID SECRETION IN WOMEN WITH AMENORRHEA
NILLIUS, SJ
WIDE, L
[J]. UPSALA JOURNAL OF MEDICAL SCIENCES, 1977, 82 (01) : 21 - 26
[8] INHIBITION OF OVULATION IN WOMEN BY CHRONIC TREATMENT WITH A STIMULATORY LRH ANALOG - NEW APPROACH TO BIRTH-CONTROL
NILLIUS, SJ
BERGQUIST, C
WIDE, L
[J]. CONTRACEPTION, 1978, 17 (06) : 537 - 545
[9] NILLIUS SJ, 1976, BASIC APPLICATIONS C, P291
[10] SHORT-TERM REGULATION OF LH AND FSH SECRETION IN CYCLIC WOMEN .2. INITIAL AUGMENTATION AND SUBSEQUENT DIMINUTION OF GONADOTROPIN-SECRETION IN RESPONSE TO 6 REPEATED LH-RH INJECTIONS AT SHORT INTERVALS
ROMMLER, A
BAUMGARTEN, S
SCHNELLER, E
SCHWARTZ, U
HAMMERSTEIN, J
[J]. ACTA ENDOCRINOLOGICA, 1978, 88 (04): : 633 - 642

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