REACTIVITY OF ORGANOPHOSPHORUS COMPOUNDS .24. ACIDIC HYDROLYSIS OF DIALKYL METHYLPHOSPHONATES

被引：13
作者：
CADOGAN, JIG
EASTLICK, D
HAMPSON, F
MACKIE, RK
机构：
[1] Department of Chemistry, University of St. Andrews, St. Andrews
来源：
JOURNAL OF THE CHEMICAL SOCIETY B-PHYSICAL ORGANIC | 1969年 / 02期
关键词：
D O I：
10.1039/j29690000144
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Rates of acidic hydrolysis of dialkyl methylphosphonates [(RO) 2P(O)Me and (RO)(EtO)P(O)Me, where R is primary, secondary (mainly), and tertiary] at 100° in 50% aqueous dioxan, containing benzenesulphonic acid (1N), have been measured and the relative rates of hydrolysis are compared with the previously reported relative rates of ageing of phosphonylated cholinesterases.
引用
收藏
页码：144 / &
相关论文
共 13 条
[1]   ON MECHANISM OF AGEING OF PHOSPHONYLATED CHOLINESTERASES [J].
BENSCHOP, HP ;
KEIJER, JH .
BIOCHIMICA ET BIOPHYSICA ACTA, 1966, 128 (03) :586-&
[2]  
CADOGAN JIG, 1969, J CHEM SOC B, P138
[3]  
CADOGAN MIG, 1967, J CHEM SOC C, P1356
[4]   DEALKYLATION STUDIES ON INHIBITED ACETYLCHOLINESTERASE [J].
COULT, DB ;
MARSH, DJ ;
READ, G .
BIOCHEMICAL JOURNAL, 1966, 98 (03) :869-&
[5]   MECHANISMS OF NUCLEOPHILIC SUBSTITUTION IN PHOSPHATE ESTERS [J].
COX, JR ;
RAMSAY, OB .
CHEMICAL REVIEWS, 1964, 64 (04) :317-&
[6]   DEALKYLATION AS A MECHANISM FOR AGING OF CHOLINESTERASE AFTER POISONING WITH PINACOLYL METHYLPHOSPHONOFLUORIDATE [J].
FLEISHER, JH ;
HARRIS, LW .
BIOCHEMICAL PHARMACOLOGY, 1965, 14 (05) :641-+
[7]  
FROST AA, 1961, KINETICS MECHANISM, P171
[8]   DEALKYLATION AND HYDROLYSIS OF ALKYL PHOSPHITES, PHOSPHATES, AND PHOSPHONATES [J].
GERRARD, W ;
GREEN, WJ ;
NUTKINS, RA .
JOURNAL OF THE CHEMICAL SOCIETY, 1952, (OCT) :4076-4078
[9]  
HUDSON RF, 1956, J CHEM SOC, P2465
[10]  
KEAY L, 1963, J ORG CHEM, V28, P1426
12