OKADAIC ACID INHIBITS INSULIN STIMULATION OF BOTH ORNITHINE DECARBOXYLASE AND SPERMIDINE TRANSPORT IN HEPATOCYTE CULTURES

被引：4

作者：

COLOMBATTO, S

GRILLO, MA

机构：

[1] Dipartimento di Medicina e Oncologia Sperimentale, Sezione di Biochimica, Universita' di Torino, Torino

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1993年 / 25卷 / 05期

关键词：

D O I：

10.1016/0020-711X(93)90355-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Okadaic acid inhibited basal ODC activity in rat hepatocytes in culture and prevented any increase in ODC activity and in the rate of spermidine uptake promoted by both insulin and hypotonicity. 2. The increase promoted by AIB was not counteracted by okadaic acid.

引用

收藏

页码：697 / 700

页数：4

相关论文

共 25 条

[1] INTERACTIONS OF OKADAIC ACID WITH INSULIN ACTION IN HEPATOCYTES - ROLE OF PROTEIN PHOSPHATASES IN INSULIN ACTION [J].

AGIUS, L ;

PEAK, M .

BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1095 (03) :243-248

[2] THE ROLE OF CELL SWELLING IN THE STIMULATION OF GLYCOGEN-SYNTHESIS BY INSULIN [J].

ALHABORI, M ;

PEAK, M ;

THOMAS, TH ;

AGIUS, L .

BIOCHEMICAL JOURNAL, 1992, 282 :789-796

[3]

BAQUET A, 1990, J BIOL CHEM, V265, P955

[4] INHIBITORY EFFECT OF A MARINE-SPONGE TOXIN, OKADAIC ACID, ON PROTEIN PHOSPHATASES - SPECIFICITY AND KINETICS [J].

BIALOJAN, C ;

TAKAI, A .

BIOCHEMICAL JOURNAL, 1988, 256 (01) :283-290

[5] INSULIN ACTION IN NORMAL AND PROTEIN-KINASE C-DEFICIENT RAT HEPATOMA-CELLS - EFFECTS ON PROTEIN-PHOSPHORYLATION, PROTEIN-KINASE ACTIVITIES, AND ORNITHINE DECARBOXYLASE ACTIVITIES AND MESSENGER-RIBONUCLEIC-ACID LEVELS [J].

BLACKSHEAR, PJ ;

NEMENOFF, RA ;

HOVIS, JG ;

HALSEY, DL ;

STUMPO, DJ ;

HUANG, JK .

MOLECULAR ENDOCRINOLOGY, 1987, 1 (01) :44-52

[6] OKADAIC ACID - A NEW PROBE FOR THE STUDY OF CELLULAR-REGULATION [J].

COHEN, P ;

HOLMES, CFB ;

TSUKITANI, Y .

TRENDS IN BIOCHEMICAL SCIENCES, 1990, 15 (03) :98-102

[7] TRANSPORT AND METABOLISM OF POLYAMINES IN HUMAN-LYMPHOCYTES [J].

COLOMBATTO, S ;

FASULO, L ;

FULGOSI, B ;

GRILLO, MA .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 1990, 22 (05) :489-492

[8]

COLOMBATTO S, 1993, IT J BIOCH

[9]

CORVERA S, 1991, J BIOL CHEM, V266, P9271

[10] EFFECTS OF OKADAIC ACID ON THE ACTIVITIES OF 2 DISTINCT PHOSPHATIDATE PHOSPHOHYDROLASES IN RAT HEPATOCYTES [J].

GOMEZMUNOZ, A ;

HATCH, GM ;

MARTIN, A ;

JAMAL, Z ;

VANCE, DE ;

BRINDLEY, DN .

FEBS LETTERS, 1992, 301 (01) :103-106