AMINONUCLEOSIDES AND THEIR DERIVATIVES .4. SYNTHESIS OF THE 3'-AMINO-3'-DEOXYNUCLEOSIDE 5'-PHOSPHATES

被引：40

作者：

AZHAYEV, AV ^{[1
]}

OZOLS, AM ^{[1
]}

BUSHNEV, AS ^{[1
]}

DYATKINA, NB ^{[1
]}

KOCHETKOVA, SV ^{[1
]}

VICTOROVA, LS ^{[1
]}

KUKHANOVA, MK ^{[1
]}

KRAYEVSKY, AA ^{[1
]}

GOTTIKH, BP ^{[1
]}

机构：

[1] MOSCOW FINE CHEM TECHNOL INST,MOSCOW 119435,USSR

来源：

NUCLEIC ACIDS RESEARCH | 1979年 / 6卷 / 02期

关键词：

D O I：

10.1093/nar/6.2.625

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new procedure hes been developed for the synthesis of 3′-amino-3′-deoxyribonucleosides of adenine, cytosine end uracil by condensing the trimethylsilylated bases with peracylated 3-azido-3-deoxyribose derivative. The azido group could subsequently be reduced to amino. The 5′-Phosphates of these nucleosides have been prepared and the analogues have been tested for their ability to stimulate the ribosome-catalyzed reaction of 3′(2′)-O-(N-formylmethionyl)edenosine 5′-phosphate with phenylslenyl-tRNA. © 1979 Information Retrieval Limited.

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页码：625 / 643

页数：19

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