Mantle cell lymphoma

被引：0

作者：

Le Gouill, Steven ^{[1
,2
,3
,4
]}

Dousset, Christelle ^{[2
,3
]}

Gastinne, Thomas ^{[1
,2
]}

Brousseau, Carole ^{[3
]}

Peterlin, Pierre ^{[1
]}

Touzeau, Cyrille ^{[1
]}

Pellat-Deceunynck, Catherine ^{[3
]}

Amiot, Martine ^{[3
]}

Moreau, Anne ^{[5
]}

机构：

[1] CHU Nantes, Serv Hematol Clin, Nantes, France

[2] CHU Nantes, Unite Rech Clin Oncohematol, Nantes, France

[3] Inserm UMR 892, Ctr Rech Cancerol Nantes Angers, Nantes, France

[4] CHU Nantes, Ctr Invest Clin Cancerol CI2C, Nantes, France

[5] CHU Nantes, Serv Anatomopathol, Nantes, France

来源：

HEMATOLOGIE | 2011年 / 17卷 / 05期

关键词：

mantle cell lymphoma; review;

D O I：

10.1684/hma.2011.0638

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mantle cell lymphoma (MCL) is a B-cell malignancy that accounts approximately for 5 to 8% of non-Hodgkin's lymphomas. The hallmark of MCL is the presence of the t(11; 14) that is responsible forover expression of protein cyclin D1 and cell cycle dysregulation. The expected overall survival from time of diagnosis has doubled in less than a decade and is around 5 years. However, despite major advances regarding our understanding of MCL physiopathology and treatment, MCL remains an incurable disease. Herein, we summarize the morphology and immunophenotype of MCL cells and clinical features at diagnosis. Frontlines strategies are presented and novel treatment options are discussed.

引用

页码：322 / 330

页数：9

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